Arterial hypertension caused by paediatric adenomas or tumours of the adrenal cortex or medulla has been associated with various hypertension-related neurological manifestations.

Idiopathic intracranial hypertension (IIH), a disorder of unclear pathophysiology characterised by increased cerebrospinal fluid (CSF) pressure, has been described in children with hypercortisolism, adrenal insufficiency, and hyperaldosteronism, reflecting the potential underlying involvement of the adrenal-brain axis in the regulation of CSF pressure homeostasis. Exposure to excessive replacement of exogenous glucocorticoids in the paediatric age group (e.g., during treatments for adrenal insufficiency) has been reported with neurological and magnetic resonance imaging (MRI) abnormalities (e.g., delayed myelination and brain atrophy) due to potential corticosteroid-related myelin damage in the developing brain and the possible impairment of limbic system ontogenesis. Childhood Cushing syndrome can be associated with long-lasting cognitive deficits and abnormal behaviour, even after resolution of the hypercortisolism.

Based on literature review and on personal case-studies and case-series we focused on the pathophysiological and clinical implications of glucocorticoid-related, mineralcorticoid-related, and catecholamine-related paediatric nervous system involvement. Approximately 60% of patients will experience symptoms because of these high levels of hormones in the blood.Various neurological and psychiatric manifestations have been recorded in children with adrenal disorders. Some adrenal cancers, and even some benign adenomas, are functional and secrete excessive amounts of hormones. They secrete hormones and are called functional tumors, or they do not and are called non-functional tumors.

Some patients describe feeling full with no appetite because of pressure on the stomach and other abdominal organs. In adrenocortical cancer, these symptoms usually are due to pressure caused by the tumor as it compresses organs, nerves and other structures around the adrenal gland. Unfortunately, this type of pain is common and does not directly suggest a disease of the adrenal cortex. The most common symptom reported by patients with adrenocortical cancer is pain in the back or side (called the flank). Fewer than 30% of adrenocortical cancers are confined to the adrenal gland at the time of diagnosis.

Most adrenocortical cancers are found after they have been growing for years.

Over adrenaline disorder